NFL Week 17 odds: Arizona at San Francisco

The 49ers, who have already secured a playoff berth, currently lead the NFC West and can clinch the division with a victory or a Seattle loss. San Francisco can also secure a first-round bye with a win over Arizona and a Green Bay loss.

The Cardinals lost 28-13 to Chicago last week. Ryan Lindley completed 17-of-30 passes for 141 yards and an interception before giving way to backup Brian Hoyer, who didn’t fare much better in throwing for 105 yards and an interception on 11-of-19 efficiency. Arizona scored its only touchdown on a blocked field goal return by Justin Bethel late in the fourth quarter. Larry Fitzgerald recorded eight catches for 111 yards in the setback. Coach Ken Whisenhunt has said Hoyer will start this week.

San Francisco was crushed 42-13 by Seattle. Colin Kaepernick completed 19-of-36 passes for 244 yards with one late touchdown and an interception. Wide receiver Mario Manningham, previously bothered by a shoulder injury, limped out of the locker room on crutches and is out for the season with torn knee ligaments. Perhaps more importantly, San Francisco fell one-half game behind NFC North champion Green Bay in the race for the No. 2 seed and a bye. The 49ers now must win and hope the Packers lose in Minnesota in order to gain that slot.

The Cardinals have been outscored 85-23 in losing three straight at San Francisco, and fell 24-3 at home to the 49ers on Oct. 29 when John Skelton was the starter. Alex Smith was the Niners’ starter then and went 18 of 19 for 232 yards, three scores and a near-perfect passer rating of 157.1.

After starting 185 consecutive games, Justin Smith sat out last Sunday’s embarrassing loss to the Seahawks and it quickly became obvious that San Francisco needs him to advance in the playoffs. Without an active, hard-nosed Smith next to him, OLB Aldon Smith struggled to be much of a factor. Justin Smith is a solid pass-rusher and does an excellent job of tying up blockers who would normally engage Aldon Smith.

WAGERWEB.COM OPENING ODDS: 49ers -16.5 (39.5) Check our current lines.

CARDINALS NOTES: QB BRIAN HOYER made Arz. debut last week … RB BEANIE WELLS has rushed for 5 TDs in past 5 … WR LARRY FITZGERALD has TD in 3 of past 4 meetings. In career, has 1,348 rec. yards vs. SF, his 2nd most vs. opp. (1,436, Sea.). Since 2007 (incl. playoffs), leads NFL with 62 rec. TDs. WR ANDRE ROBERTS has career-highs in catches (61), yards (741) & TDs (5) … LB DARYL WASHINGTON had 2 sacks in Week 8 vs. SF. Aims for 4th in row vs. SF with sack or INT. Is 1 of 2 in NFL (CLAY MATTHEWS) with 14+ sacks, 3+ INTs & 2+ FFs since 2011. Has 10 sacks in past 16. Leads team with 123 tackles. Defense is holding opposing QBs to 68.5 rating. CB PATRICK PETERSON has INT in 4 of past 5. Rookie S JUSTIN BETHEL returned blocked FG 82 yards for TD last week. S KERRY RHODES has 3 INTs & FF in past 6. S ADRIAN WILSON is 1 of 6 in NFL history with 25+ sacks (25.5) & 25+ INTs (27). DE CALAIS CAMPBELL aims for 3rd in row vs. SF with sack. DT DARNELL DOCKETT aims for 3rd meeting in row with sack.

49ERS NOTES: QB COLIN KAEPERNICK has 97.4 rating as starter, incl. 3 starts with 100+ rating … RB FRANK GORE has 5 rush TDs in past 5 meetings at home. Has 1,146 rush yards, his 6th career 1,000-yard season … WR MICHAEL CRABTREE had 2 TDs in last meeting. In last game vs. Arz. at home, had 7 catches for 120 yards. Has 90+ yards or TD in 6 of past 8. Has 933 rec. yards & needs 67 for 1st career 1,000-yard season. Since 2009 (incl. playoffs), TE VERNON DAVIS leads NFC TEs with 35 TDs. Aims for 4th in row at home vs. Arz. with TD. TE DELANIE WALKER aims for 3rd in row with TD … Team leads NFC & ranks 2nd in NFL in total defense (296.5 yards per game). LB ALDON SMITH has 33.5 career sacks, most by player in 1st 2 seasons. Leads NFC with team-record 19.5 sacks & needs 3.5 to pass MICHAEL STRAHAN (22.5) for NFL record. Has 15 sacks in past 9. Has 4 sacks in 3 career meetings. LB NA VORRO BOWMAN leads team with 140 tackles. Had 16 tackles last week. LB PATRICK WILLIS is 2nd with 116. Had INT last week.

WAGERWEB.COM TRENDS: Under is 4-1 in the last 5 meetings in San Francisco. Favorite is 4-1 ATS in their last 5 meetings. Under is 5-2 in the last 7 meetings. Road team is 10-4 ATS in their last 14 meetings. Cardinals are 1-7 ATS in their last 8 meetings.

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